Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

A cell surface amine oxidase directly controls lymphocyte migration.

M Salmi¹, G G Yegutkin, R Lehvonen

¹MediCity Research Laboratory, Turku University and National Public Health Institute Department in Turku, Turku FIN-20520, Finland. marko.salmi@utu.fi

|April 6, 2001

Summary

Vascular adhesion molecule-1 (VAP-1) directly controls lymphocyte rolling on endothelial cells. Its catalytic activity forms a transient bond, regulating immune cell extravasation without needing reaction products.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Histological tumor necrosis predicts decreased survival after neoadjuvant chemotherapy in head and neck squamous cell carcinoma.

Oral oncology·2025

Same author

Chemical interactions in composites of gellan gum and bioactive glass: self-crosslinking and <i>in vitro</i> dissolution.

Frontiers in chemistry·2023

Same author

Long-term results for pit-picking and flap procedures in primary pilonidal sinus disease.

BMC surgery·2023

Same author

Continuation of fluoropyrimidine treatment with S-1 after cardiotoxicity on capecitabine- or 5-fluorouracil-based therapy in patients with solid tumours: a multicentre retrospective observational cohort study.

ESMO open·2022

Same author

Treatment response of colorectal cancer liver metastases to neoadjuvant or conversion therapy: a prospective multicentre follow-up study using MRI, diffusion-weighted imaging and <sup>1</sup>H-MR spectroscopy compared with histology (subgroup in the RAXO trial).

ESMO open·2021

Same author

Centralized repeated resectability assessment of patients with colorectal liver metastases during first-line treatment: prospective study.

The British journal of surgery·2021

Area of Science:

Immunology
Cell Biology
Biochemistry

Background:

Lymphocyte extravasation is crucial for immune response.
Vascular adhesion molecule-1 (VAP-1) is an endothelial glycoprotein and monoamine oxidase.

Purpose of the Study:

To investigate the role of VAP-1's catalytic activity in lymphocyte adhesion.
To elucidate the mechanism of VAP-1-mediated lymphocyte rolling.

Main Methods:

Studied primary endothelial cells and lymphocytes under laminar shear flow.
Assessed the impact of VAP-1 catalytic activity on cell adhesion.

Main Results:

VAP-1's enzymatic activity directly regulates lymphocyte rolling.
VAP-1 binds to lymphocyte amino groups, forming a transient covalent bond.

Related Experiment Videos

Soluble reaction products are not required for VAP-1-dependent rolling.

Conclusions:

Enzymatic regulation of lymphocyte adhesion by VAP-1 offers a novel mechanism.
This process provides a rapid control point for immune cell extravasation.