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Updated: Jul 23, 2026

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
Published on: November 29, 2016
The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression
R J West1, A Y Sun, D L Church
1Department of Biological Sciences, 115 Gilman, Dartmouth College, Hanover NH 03755, USA.
Abstract:
The C. elegans gon-2 gene is required for the post-embryonic mitotic cell divisions of the gonadal precursor cells. A single major transcript of approximately 6.7 kb is derived from the gon-2 locus. This mRNA encodes a protein related to the TRP family of cation channels and has a high degree of similarity to several vertebrate genes, including melastatin. Mutant alleles of gon-2 affect evolutionarily conserved amino acid residues. Northern analyses suggest that gon-2 expression is not limited to gonadal tissues.
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