Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcription factors in mouse lung development and function.

R H Costa1, V V Kalinichenko, L Lim

  • 1Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607-7170, USA.

American Journal of Physiology. Lung Cellular and Molecular Physiology
|April 6, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early onset metastatic colorectal cancer in Australia.

Cancer treatment and research communications·2024
Same author

Targeting antimicrobial stewardship in hospitalised patients with community-acquired pneumonia within 24 h of admission.

Infection, disease & health·2024
Same author

Aflibercept monotherapy versus aflibercept with targeted retinal laser to peripheral retinal ischemia for diabetic macular oedema (LADAMO).

Eye (London, England)·2023
Same author

Re-evaluation of the low-dose dexamethasone suppression test in dogs.

The Journal of small animal practice·2022
Same author

[ASSESSMENT OF PHYSICAL DEVELOPMENT OF PRESCHOOL CHILDREN OF THE REPUBLIC OF KAZAKHSTAN AND RETROSPECTIVE ANALYSIS OVER THE LAST 50 YEARS].

Georgian medical news·2021
Same author

Initial experience of TAS-102 chemotherapy in Australian patients with Chemo-refractory metastatic colorectal cancer.

Current problems in cancer·2021

Transcription factors are crucial for mouse lung development, guiding branching morphogenesis and cell differentiation. This review details key transcription factors and their roles in lung formation.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Lung development involves complex mesenchymal-epithelial interactions crucial for branching morphogenesis.
  • These interactions regulate cell proliferation, migration, and differentiation, forming the pulmonary tree and capillary bed.
  • Mesenchymal-epithelial signaling potentiates transcription factor activity essential for lung formation.

Purpose of the Study:

  • To review the critical roles of specific transcription factors in mouse lung morphogenesis.
  • To summarize the functions of these factors in maintaining differentiated gene expression within the developing lung.

Main Methods:

  • Review of existing literature on mouse lung development.
  • Analysis of phenotypes from transgenic and knockout mouse models.

Related Experiment Videos

  • Focus on key transcription factors including FoxA2, FoxF1, FoxJ1, Nkx2.1, HOXA5, Gli, GATA, and Pod1.

    • Main Results:

    • Identified key transcription factors essential for lung branching morphogenesis.
    • Demonstrated the involvement of these factors in cellular differentiation.
    • Highlighted the importance of transcription factors in maintaining lung-specific gene expression.

    Conclusions:

    • Transcription factors play indispensable roles in lung development and differentiation.
    • Understanding these factors provides insights into mechanisms of lung formation and potential therapeutic targets.