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Updated: Oct 8, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Pathophysiology and treatment of secondary obsessive-compulsive behaviors and tics
1Pediatric and Developmental Neuropsychiatry Branch, National Institute of Mental Health, 10 Center Drive, Building 10 Room 4N-208, Bethesda, MD 20892, USA.
Abstract:
Advances in neurobiological research suggest that certain frontal-subcortical circuits play important roles in idiopathic obsessive-compulsive disorder and Tourette's syndrome. Tics and obsessive-compulsive behaviors secondary to neurologic insult appear to involve the same neural circuitry. There are few systematic studies of the treatment of obsessive-compulsive behaviors and tics associated with neurologic disorders. However knowledge of the circuitry and associated neurochemistry of these disorders can help to outline a rational approach to these behaviors.
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