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Related Experiment Videos

Apathy.

T W McAllister1

  • 1Section of Neuropsychiatry, Department of Psychiatry, Dartmouth Medical School, New Hampshire Hospital, Lebanon, NH 03756, USA. Thomas.W.McAllister@Dartmouth.edu

Seminars in Clinical Neuropsychiatry
|April 6, 2001
PubMed
Summary
This summary is machine-generated.

Deficits in motivated behavior are common in neuropsychiatric disorders. Treatment strategies focus on catecholaminergic agents, particularly targeting the mesolimbic dopaminergic system, to address these challenges.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Motivated behavior deficits are a common and disabling sequela of neuropsychiatric disorders.
  • Attempts to stimulate apathy can lead to aggressive behavior.
  • Understanding the neurobiology of motivation is crucial for effective treatment.

Purpose of the Study:

  • To review the literature on the components, circuitry, and neurochemistry of motivated behavior.
  • To inform the psychopharmacologic approach to motivated behavior deficits.

Main Methods:

  • Selective review of animal and human literature on motivated behavior.
  • Focus on neurochemical and circuitry-based mechanisms.

Main Results:

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  • Motivated behavior involves specific hypothalamic regions and a midbrain-to-forebrain reward system.
  • Frontal-subcortical circuits are integral to motivated behavior.
  • Catecholaminergic systems, especially the mesolimbic dopaminergic system, are key modulators.

    • Conclusions:

    • The psychopharmacologic treatment of motivated behavior deficits should target catecholaminergic systems.
    • Catecholaminergic agents are a key therapeutic strategy for these deficits.