Related Experiment Video

Updated: Oct 8, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

[Mitral flow propagation velocity assessed with M-mode color Doppler in patients with dilated cardiomyopathy]

L Coelho1, R Pires, M Costa

  • 1Serviço de Cardiologia dos Hospitais da Universidade de Coimbra, Coimbra, Portugal.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|April 9, 2001
PubMed

Insights

Propagation velocity (PV) effectively quantifies left ventricular (LV) diastolic function in dilated cardiomyopathy. This load-independent indicator correlates with classic LV filling parameters, aiding severity assessment.

Area of Science:

  • Cardiology
  • Echocardiography
  • Diastolic Function

Background:

  • Diastolic dysfunction is often overlooked in severe left ventricular (LV) dysfunction due to quantification challenges.
  • Propagation velocity (PV) of mitral inflow is a proposed load-independent indicator of LV diastolic function.
  • This study aimed to validate PV in quantifying LV filling and risk stratification in dilated cardiomyopathy (DC).

Purpose of the Study:

  • Correlate PV with patient characteristics and classic systolic and diastolic function parameters.
  • Validate PV as an indicator of LV filling.
  • Assess PV's utility in risk stratification for DC patients.

Main Methods:

  • Prospective study of 32 DC patients with low ejection fraction.
  • Echocardiographic assessment of LV systolic function (ejection fraction, fractional shortening, cardiac output).
  • Transmitral flow Doppler analysis (IVRT, E/A ratio, DT) and Tei index.
  • PV calculated using Color M-mode echocardiography.

Main Results:

  • High prevalence of diastolic dysfunction (78.1% delayed relaxation, 9.4% restrictive pattern).
  • PV showed no correlation with age, body surface, or LV geometry.
  • Significant correlations found between PV and E/A ratio (r=0.61), IVRT (r=-0.50), DT (r=-0.41), and Tei index (r=-0.36).

Conclusions:

  • PV strongly correlates with classic LV filling parameters in patients with predominant delayed relaxation.
  • PV is a potentially easy, fast, and reproducible quantitative indicator of DC severity.
  • PV may aid in assessing LV diastolic function and severity in DC patients.
Abstract

More Related Videos

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 9, 2010

Transthoracic Echocardiography in Mice08:09

Transthoracic Echocardiography in Mice

Published on: May 28, 2010

Related Concept Videos

Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...