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Long-term renal dysfunction in patients with acute urinary retention
S Mustonen1, I O Ala-Houhala, T L Tammela
1Division of Urology, Tampere University Hospital, Finland. s.musto@fimnet.fi
Scandinavian Journal of Urology and Nephrology
|April 9, 2001
Summary
Acute urinary retention (AUR) can cause lasting kidney damage. This study found permanent tubular dysfunction but partial recovery of glomerular function in patients with persistent renal dysfunction after AUR.
Area of Science:
- Nephrology
- Urology
- Renal Medicine
Background:
- Acute urinary retention (AUR) leads to bilateral renal obstruction, impacting kidney function.
- Long-term effects of AUR on renal function require further investigation.
Purpose of the Study:
- To evaluate long-term glomerular and tubular renal function after resolution of acute urinary retention (AUR).
Main Methods:
- Renal function was re-evaluated in 15 patients with persistent renal dysfunction 18 months after AUR resolution.
- Bladder outlet obstruction was treated, and normal voiding was confirmed at 6 months.
Main Results:
- Elevated alpha1-microglobulin excretion and lowered creatinine clearance increased over time post-AUR.
- 100% of patients showed elevated alpha1-microglobulin excretion by 18 months.
- 69% of patients had abnormally high daily protein excretion at 18 months, with generally mild abnormalities.
Conclusions:
- Patients with persistent renal dysfunction post-AUR demonstrated permanent tubular impairment.
- Glomerular permeability showed partial recovery.
- Urgent AUR treatment is crucial to prevent renal failure, even with mild impairment.
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