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Characterization of nonfermenters from clinical samples
N V Kharangate1, M J Pinto, S Rodrigues
1Department of Microbiology, Goa Medical College, Bambolim.
The Journal of the Association of Physicians of India
|April 9, 2001
Summary
Nonfermenting gram-negative bacilli, primarily Pseudomonas and Acinetobacter, cause various infections. Amikacin and ciprofloxacin show effectiveness against these multidrug-resistant organisms.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Nonfermenters are aerobic, non-sporing, gram-negative bacilli commonly found in nature.
- These organisms possess established pathogenic potential, contributing to various human infections.
Purpose of the Study:
- To evaluate the role of nonfermenting gram-negative bacilli in diverse clinical infections.
- To characterize isolates of nonfermenters from clinical specimens.
Main Methods:
- 100 nonfermenter isolates from clinical samples were analyzed.
- Isolates were grouped using the Weaver-Hollis scheme and identified via biochemical tests.
- Antimicrobial susceptibility testing was performed on all isolates.
Main Results:
- Most isolates (50%) were from pus and urine samples.
- Pseudomonas species constituted 56% of the isolates.
- Multidrug resistance was prevalent; amikacin and ciprofloxacin demonstrated the highest efficacy.
Conclusions:
- Nonfermenting gram-negative organisms are significant causes of infection.
- Pseudomonas and Acinetobacter calcoaceticus were the most frequently identified genera.
- Amikacin or ciprofloxacin are recommended as first-line treatments for infections caused by these nonfermenters.