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Toxic effect of troglitazone on cultured rat hepatocytes
Y Toyoda1, A Tsuchida, E Iwami
1Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Life Sciences
|April 9, 2001
Abstract:
We examined the cytotoxicity of troglitazone toward cultured rat hepatocytes. The drug concentration- and time-dependently decreased cell viability and increased lactate dehydrogenase leakage from the cells. Troglitazone-induced cell death was characterized by "DNA ladders", condensation of nuclei, and a positive reaction to in situ nick-end labeling. The results indicate that troglitazone can cause apoptotic cell death in cultured rat hepatocytes.