Developmental changes in cerebrospinal fluid concentrations of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy
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Published on: November 10, 2008
Y Takeuchi1, H Matsushita, H Sakai
1Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Japan. takeuchi@belle.shiga-med.ac.jp
Abstract:
Using a Coulochem electrode array system, we investigated the developmental changes of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy. The patterns observed in the developmental changes of tryptophan, tyrosine, homovanillic acid (HVA), 3-O-methyldopa, and 3-methoxy4-hydroxyphenyl glycol (MHPG) in patients with dentatorubral-pallidoluysian atrophy are quite different from those in control subjects. These abnormal developmental changes in monoamine-related substances may be implicated in age-related differences in clinical symptoms of dentatorubral-pallidoluysian atrophy.
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