Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signal transduction in thymus development.

J Sen1

  • 1Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA. Jytoi_Sen@DFCI.harvard.edu

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|April 9, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stress response after race and endurance training sessions and competitions in Arabian horses.

Preventive veterinary medicine·2021
Same author

Identification and validation of two peptide markers for the recognition of Clostridioides difficile MLST-1 and MLST-11 by MALDI-MS.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
Same author

Impact of a structured oculoplastic surgery rotation on specialist training in oral and maxillofacial surgery.

The British journal of oral & maxillofacial surgery·2018
Same author

Dermatoglyphic variation among the Limboo of Sikkim, India.

Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen·2015
Same author

The usefulness of the Loewenstein Occupational Therapy Cognition Assessment in evaluating cognitive function in patients with stroke.

European review for medical and pharmacological sciences·2014
Same author

In vitro propagation of Coleus forskohlii Briq. for forskolin synthesis.

Plant cell reports·2013
Same journal

Differential effects of high-sucrose and high-fat diets on metabolic syndrome, BBB integrity, and hippocampal Aβ accumulation.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

CRISPR systems in cancer therapeutics and diagnostics.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

Sex-specific effects of fluoxetine on REM sleep deprivation-induced behavioral impairments and BDNF downregulation in rats.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

Gene polymorphism and serum level of RANKL among patients with rheumatoid arthritis: a systematic review and meta-analysis.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

Effect of peniocerol on human meniscal fibrochondrocyte inflammation induced by IL-1β and TNF-α through the NF-κB signaling pathway.

Cellular and molecular biology (Noisy-le-Grand, France)·2026
Same journal

Integrated density functional theory, molecular docking, and pharmacokinetic modeling of mukonal and its derivatives as inhibitors of the Plasmodium falciparum TFIIH complex (Tfb5 subunit).

Cellular and molecular biology (Noisy-le-Grand, France)·2026
See all related articles

The thymus generates diverse T-cells through interactions between bone marrow precursors and the thymic environment. Despite age-related decline, the involuted thymus can still produce new T-cells, highlighting crucial signaling pathways in thymopoiesis.

Area of Science:

  • Immunology
  • Developmental Biology

Background:

  • T-cell development is crucial for adaptive immunity.
  • The thymus provides a specialized microenvironment for T-cell maturation.
  • Bone marrow precursors migrate to the thymus for T-cell generation.

Purpose of the Study:

  • To describe the fundamental features of developing thymocytes.
  • To elucidate the role of the thymic micro-environment in T-cell development.
  • To highlight signaling pathways regulating thymopoiesis.

Main Methods:

  • Review of existing literature on thymopoiesis.
  • Analysis of cell-cell interactions, cytokines, chemokines, and hormones.
  • Examination of signaling cascades regulating cell fate, proliferation, and death.

Related Experiment Videos

Main Results:

  • Thymic micro-environment signals guide T-cell differentiation from precursors.
  • Stage-specific signals balance proliferation, differentiation, survival, and death.
  • The involuted adult thymus retains the capacity for T-cell generation.

Conclusions:

  • Reciprocal interactions between precursors and the thymic stroma are essential for T-cell repertoire generation.
  • Signaling pathways within the thymus orchestrate T-cell development.
  • Understanding these pathways is key to addressing age-related decline in T-cell immunity.