Presence and possible functional role of nerve growth factor in the thymus

We have previously reported that the nerve growth factor (NGF), a polypeptide known for its neurotrophic activities, is also involved in proliferation, growth and survival of cells of the immune system. Working with animal models, we found that NGF and NGF-receptors (NGF-r) are present in the cells of the medullary layer of the thymus, a lymphoid gland involved in the production and differentiation of T-lymphocytes. Using immunohistochemical and biochemical approaches, we also showed that the expression of NGF in the thymus is high during late prenatal life and decreases later in postnatal life. A significant alteration of NGF levels was also found during pregnancy and aging, two events characterized by thymic involution. The aim of this study is to investigate whether NGF and NGF-r expression in the thymus are influenced by immuno- and neuro-pathological events. These observations will be presented and discussed.