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Hyaluronan in morphogenesis.

B P Toole1

  • 1Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA. bryan.toole@tufts.edu

Seminars in Cell & Developmental Biology
|April 9, 2001
PubMed
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Hyaluronan, a large polysaccharide, forms a hydrated matrix at the cell surface. Its unique properties and interactions are crucial for cell signaling, behavior, and embryonic development.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Developmental Biology

Background:

  • Hyaluronan (HA) is a large polysaccharide abundant in extracellular matrices and at cell surfaces.
  • It forms the core of a hydrated pericellular matrix, interacting with various hyaladherins.
  • HA plays roles both inside and outside cells, influencing cellular environments and signaling.

Purpose of the Study:

  • To review the functions of hyaluronan specifically at the cell surface.
  • To explore the molecular characteristics of HA contributing to its physiological roles.
  • To highlight the importance of HA in embryonic development and morphogenesis.

Main Methods:

  • Literature review focusing on cell surface hyaluronan functions.
  • Analysis of hyaluronan's hydrodynamic properties, hyaladherin interactions, and cell signaling effects.

Related Experiment Videos

  • Examination of data from hyaluronan-deficient mouse embryos.

    • Main Results:

    • Hyaluronan's functions stem from its hydrodynamic properties, interactions with hyaladherins, and effects on cell signaling.
    • Studies on hyaluronan-deficient embryos underscore the significance of these functions.
    • HA acts as a template for pericellular matrix assembly, influencing cell separation and signaling.

    Conclusions:

    • Hyaluronan's cell surface functions are critical for establishing a hydrated pericellular environment.
    • Its physical properties and interactions modulate cell signaling and behavior.
    • HA is essential for embryonic morphogenesis by organizing the pericellular matrix and mediating developmental signals.