Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic solid-state and tableting properties of four theophylline forms.

E Suihko1, V P Lehto, J Ketolainen

  • 1Department of Pharmaceutics, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland. eero.suihko@uku.fi

International Journal of Pharmaceutics
|April 9, 2001
PubMed
Summary

Theophylline solid-state forms undergo transformations during storage, impacting their densification and compact properties. Water content significantly influences these changes, affecting drug formulation stability.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unlocking Protein Evolution Insights: Efficient and Interpretable Mutational Effect Predictions with GEMME.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

A feasible approach to measure metal concentrations in drill hole waters on site for mineral exploration.

The Science of the total environment·2024
Same author

Effect of Molecules' Physicochemical Properties on Whey Protein/Alginate Hydrogel Rheology, Microstructure and Release Profile.

Pharmaceutics·2024
Same author

Multiple Profile Models Extract Features from Protein Sequence Data and Resolve Functional Diversity of Very Different Protein Families.

Molecular biology and evolution·2022
Same author

Risk factors for post-operative complications after sentinel lymph node biopsy for cutaneous melanoma: Results from a large cohort study.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2019
Same author

Containing a measles outbreak in Minnesota, 2017: methods and challenges.

Perspectives in public health·2019

Area of Science:

  • Pharmaceutical Sciences
  • Solid-State Chemistry
  • Materials Science

Background:

  • Theophylline exists in various solid-state forms, including monohydrate (TMO), a mixture (TMIX), and anhydrous polymorphs I (TA-I) and II (TA-II).
  • Understanding the relationships between these forms and their physical properties is crucial for pharmaceutical development.

Purpose of the Study:

  • To investigate the solid-state transformations of theophylline forms.
  • To evaluate the impact of these transformations on densification and compact properties.
  • To determine the influence of water content on these behaviors.

Main Methods:

  • Powder X-ray diffraction for solid-state identification.
  • Compaction simulator for assessing deformation and preparing compacts.

Related Experiment Videos

  • Porosity and tensile strength measurements after storage at controlled humidity.

    • Main Results:

    • Theophylline anhydrous polymorph II (TA-II) is the stable form; TA-I, TMIX, and TMO transform to TA-II during storage.
    • All forms primarily deform via plastic flow, with water content increasing viscoelasticity in TMIX and TMO.
    • Densification and tensile strength of TMIX and TMO compacts change over time, approaching TA-II properties.

    Conclusions:

    • Dynamic solid-state transformations influence theophylline's densification and compact properties.
    • Water content plays a critical role in the extent of these property changes.
    • These findings are vital for predicting and controlling the stability of theophylline formulations.