Induction of extra nephrons in unilaterally nephrectomized immature rats (38525)

The normal number of glomeruli per kidney in the rat rises from about 10-4 at birth to approximately 35 times 10-3 at 50 days of age. When one kidney is removed at birth the remaining one produces an average of 63% more nephrons than normal by 70 days. Unilateral nephrectomy of successively older rats results in progressively less augmentation of the nephron complement in the remaining kidney up to 50 days, beyond which age the kidney loses its ability to produce new nephrons.