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Passive immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus
A L Rosas1, J D Nosanchuk, A Casadevall
1Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Infection and Immunity
|April 9, 2001
Abstract:
Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison to controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection.