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Sequence and antigenic variability of the Helicobacter mustelae surface ring protein Hsr
N Forester1, J S Lumsden, T O'Croinin
1Institute of Molecular BioSciences, Massey University, Palmerston North, New Zealand.
Infection and Immunity
|April 9, 2001
Abstract:
We have identified an array of more than 500 repetitive sequences flanking the hsr gene, which encodes the major surface protein of the ferret pathogen Helicobacter mustelae. The repeats show identity exclusively to the amino-terminal half of Hsr. Analysis of Hsr from three strains indicated variability of exposed epitopes. Characterization of an hsr mutant showed that Hsr is not an adhesin.