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Evolving antimicrobial chemotherapy for Staphylococcus aureus infections: Our backs to the wall
1University of Chicago, the Department of Pediatrics, the Section of Pediatric Infectious Diseases, Chicago, IL, USA.
Critical Care Medicine
|April 9, 2001
Abstract:
Staphylococcus aureus is responsible for many nosocomial and community-acquired infections. Its evolving resistance to traditional antimicrobial chemotherapy and emerging prevalence outside of the healthcare environment are serious concerns. This review of the changing epidemiology of methicillin-resistant S. aureus, the emergence of vancomycin (glycopeptide)-resistant isolates, and the mechanisms of resistance to beta-lactams and glycopeptides provides an update for clinicians regarding effective strategies for treatment.