Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mediastinal lymph node evaluation by computed tomographic scan in lung cancer.

M Kamiyoshihara1, O Kawashima, S Ishikawa

  • 1Department of Surgery, National Sanatorium Nishi-Gunma Hospital, Shibukawa, Gunma, Japan. kamiyosi@sa2.so-net.ne.jp

The Journal of Cardiovascular Surgery
|April 9, 2001
PubMed
Summary

Computed tomography (CT) has limited accuracy for lung cancer N-staging. CT scan results require careful interpretation, especially in heavy smokers and adenocarcinoma cases, to avoid misdiagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tracheobronchial stenosis evaluated by inspiratory and expiratory three-dimensional computed tomography and impulse oscillation with three-dimensional color imaging in a patient with relapsing polychondritis.

Journal of biological regulators and homeostatic agents·2014
Same author

ASC amino-acid transporter 2 (ASCT2) as a novel prognostic marker in non-small cell lung cancer.

British journal of cancer·2014
Same author

Clinicopathological and prognostic significance of interleukin-8 expression and its relationship to KRAS mutation in lung adenocarcinoma.

British journal of cancer·2014
Same author

Unanticipated troubles in video-assisted thoracic surgery: a proposal for the classification of troubleshooting.

Asian journal of endoscopic surgery·2012
Same author

Effect of landiolol hydrochloride, an ultra-short-acting beta 1-selective blocker, on supraventricular tachycardia, atrial fibrillation and flutter after pulmonary resection.

Journal of clinical pharmacy and therapeutics·2011
Same author

[Surgical treatment for secondary pneumothorax in elderly patients].

Kyobu geka. The Japanese journal of thoracic surgery·2011

Area of Science:

  • Oncology
  • Radiology
  • Thoracic Surgery

Background:

  • Computed tomography (CT) is a standard preoperative tool for evaluating mediastinal lymph node involvement in lung cancer.
  • The diagnostic accuracy of CT for N-staging in lung cancer remains a subject of debate.
  • This study investigates the predictive capability of CT scans for N-staging in lung cancer patients.

Purpose of the Study:

  • To assess the accuracy of computed tomography (CT) in predicting N-staging for lung cancer.
  • To analyze the discrepancy between clinical N-staging by CT and pathological findings.
  • To identify factors influencing the accuracy of CT-based N-staging.

Main Methods:

  • A retrospective analysis of 546 patients with primary pulmonary adenocarcinoma and squamous cell carcinoma who underwent preoperative CT and subsequent surgical resection with lymph node dissection between 1981 and 1996.

Related Experiment Videos

  • Nodes were considered abnormal if their short axis exceeded 1.0 cm.
  • Statistical analysis was performed to evaluate sensitivity, specificity, and accuracy, and to identify significant differences based on various patient and tumor characteristics.

    • Main Results:

    • The overall sensitivity, specificity, and accuracy of CT for N-staging were 33.0%, 90.4%, and 78.9%, respectively.
    • No significant differences in CT performance were observed based on the year of scan or the type of scanning device used.
    • Statistically significant variations in sensitivity and specificity were noted concerning histologic type, gender, tumor size, Brinkman index, tumor location, and serum CEA levels.

    Conclusions:

    • Clinicians should be aware of potential false positives in heavy smokers (or males) and false negatives in adenocarcinoma, tumors larger than 3 cm, or cases with rising serum CEA values, even with negative CT lymph node findings.
    • CT scan findings for mediastinal lymph node evaluation in lung cancer require careful consideration of patient-specific factors and tumor characteristics.
    • The study highlights the need for a nuanced interpretation of CT results in lung cancer staging.