Related Experiment Video
Updated: Aug 17, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
The effect of mineralocorticoid deficiency on renal concentrating and diluting capacity
Abstract:
To examine the effect of mineralocorticoid deficiency on sodium transport by the ascending limb of the loop of Henle, free water clearance and reabsorption were measured in the same six dogs under conditions of aldosterone deficiency and mineralocorticoid sufficiency. Aldosterone deficiency was induced by bilateral adrenalectomy with dexamethasone replacement. H2O/100 ML GFR ranged from 4.0 to 19.5 in the aldosterone deficient dogs and 4.5-18.6 in the mineralocorticoid sufficient dogs. H2O/100 ML GFR plotted against V/100 ML GFR showed no significant difference between the two groups. H2O/100 ml GFR ranged from 1.2 to 6.5 in the mineralocorticoid sufficient group and 2.4-8.5 in the mineralcorticoid sufficient group and 2.4-8.5 in the aldosterone deficient group. TC-H2O/100 GFR plotted against Osm/100 ml GFR revealed no significant urine concentration in the mineralocorticoid sufficient group was 1356 mOsm/kg plus or minus 254 (SD) and 1386 mOsm/kg plus or minus 331 (SD) for the aldosterne deficient group; the difference is not significant. This study failed to demonstrate any effect of aldosterone deficiency on renal concentrating and diluting capacity and thus provides inferential evidence against an effect of aldosterone on ascending limb sodium reabsorption.
Related Concept Videos
Antihypertensive Drugs: Potassium-Sparing Diuretics
Renal Tubule and Collecting Duct
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Formation of Dilute Urine
Filtrate Osmolarity in the PCT
Initially, as the filtrate passes through the proximal convoluted tubule (PCT), its...
Formation of Concentrated Urine
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion
Physiology of the Genitourinary System III: Urine Concentration and Dilution

