Transplanted peripheral blood stem cells, mobilized by chemotherapy alone, can induce persistent hematopoiesis in

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Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
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T Kudoh1, S Katoh, N Suzuki

  • 1Department of Pediatrics, School of Medicine, Sapporo Medical University, S1 W16, Chuo-ku, Sapporo, 060-8543, Japan. tkudoh@sapmed.ac.jp

Pediatric Hematology and Oncology
|April 11, 2001
PubMed

Three patients with leukemia were transplanted with peripheral blood stem cells mobilized by intensification or maintenance chemotherapy alone. They maintained persistent reconstituted hematopoiesis for at least 9 years. The experience provides evidence that long-term marrow repopulating cells can be mobilized into the blood to an adequate repopulating extent by chemotherapy alone.

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