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Related Experiment Videos

Soluble L-selectin levels during controlled ovarian hyperstimulation.

R Orvieto1, Z Ben-Rafael, A Schwartz

  • 1Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva, Israel.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|April 11, 2001
PubMed
Summary

Human chorionic gonadotropin (hCG) administration during controlled ovarian hyperstimulation (COH) activates neutrophils, indicated by rising soluble L-selectin levels. This immune response correlates with progesterone, suggesting a link between luteinization and neutrophil activation in COH.

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Area of Science:

  • Reproductive Endocrinology
  • Immunology
  • In Vitro Fertilization

Background:

  • Controlled ovarian hyperstimulation (COH) is a key component of in vitro fertilization (IVF).
  • Neutrophil activation, a component of the immune response, has been hypothesized to play a role in COH.
  • Soluble L-selectin is a marker of neutrophil activation.

Purpose of the Study:

  • To investigate neutrophil activation during COH using soluble L-selectin levels.
  • To explore the correlation between soluble L-selectin and serum sex steroid levels during COH.

Main Methods:

  • Study included 14 patients undergoing a standard IVF long GnRH analog protocol.
  • Blood samples were collected at three time points: Day-S (suppression), Day-hCG (hCG administration), and Day-OPU (ovum pick-up).

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  • Soluble L-selectin, estradiol, progesterone, and hCG levels were measured using ELISA and other assays.

    • Main Results:

    • Soluble L-selectin levels were significantly higher on Day-OPU compared to Day-S and Day-hCG.
    • Soluble L-selectin levels were significantly lower on Day-hCG compared to Day-S.
    • A positive correlation was observed between soluble L-selectin and serum progesterone levels, but not with estradiol or hCG.

    Conclusions:

    • hCG administration during COH induces neutrophil activation.
    • Neutrophil activation during COH correlates with the degree of luteinization, as indicated by progesterone levels.
    • Further research is needed to understand the immune system's role in COH and its potential clinical applications.