[Granulocytes transfusion for neutropenic patients]

A renewed interest in the transfusion of granulocytes for support of patients afflicted by severe and prolonged neutropenia has resulted from improved methods of mobilization and collection that provide cellular products superior in number and functions as compared with historical experiences of the 70's. In this review we discuss the clinical experience reported in the literature over the past three decades, the progress made in donor selection, the use of growth factors and mechanical apheresis. We comment on adverse effects, emphasize present indications and our own experience for the use of granulocyte transfusions. Hopefully, the progress made in this area will justify the consideration of granulocyte transfusions in the management of the severely neutropenic patient and provide proper documentation to avoid repeating the disappointment experienced in the previous two decades.