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Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium
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Published on: February 11, 2009

Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition

G Thoma1, J L Magnani, J T Patton

  • 1Novartis Pharma AG, Basel, Switzerland. gebhard.thoma@pharma.novartis.com

Bioorganic & Medicinal Chemistry Letters
|April 11, 2001
PubMed

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Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...