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Water-soluble propofol analogues with intravenous anaesthetic activity
A Cooke1, A Anderson, K Buchanan
1Department of Medicinal Chemistry and Pharmacology, Organon Laboratories Ltd., Newhouse, Scotland, UK. a.cooke@organon.nhe.akzonobel.nl
Bioorganic & Medicinal Chemistry Letters
|April 11, 2001
Abstract:
Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents.