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Bile acid-oligodeoxynucleotide conjugates: synthesis and liver excretion in rats
D Starke1, K Lischka, P Pagels
1Institute of Pharmacology and Toxicology, Justus-Liebig-University, Giessen, Germany.
Bioorganic & Medicinal Chemistry Letters
|April 11, 2001
Abstract:
The synthesis of bile acid oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid-oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.