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Related Experiment Videos

Update on immunoisolation cell therapy for CNS diseases.

D F Emerich1, H C Salzberg

  • 1Department of Neuroscience, Alkermes, Inc, Cambridge, MA 02139, USA.

Cell Transplantation
|April 11, 2001
PubMed
Summary

Cellular implants using polymer encapsulation, or immunoisolation, can overcome the blood-brain barrier (BBB) to deliver therapeutics directly to the central nervous system (CNS). This method protects cells from immune rejection, avoiding the need for immunosuppression.

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Drug Delivery

Background:

  • The blood-brain barrier (BBB) significantly impedes drug delivery to the brain.
  • Cellular implants offer a strategy to bypass the BBB for localized therapeutic molecule production and delivery.
  • Polymer encapsulation, termed immunoisolation, protects xenogeneic cells within semipermeable membranes.

Purpose of the Study:

  • To review advancements in cell immunoisolation for treating central nervous system (CNS) diseases.
  • To discuss device configurations and membrane manufacturing for immunoisolatory implants.
  • To highlight the application of immunoisolation in preclinical models of neurodegenerative diseases.

Main Methods:

  • Utilizing semipermeable membranes to encapsulate therapeutic cells, allowing nutrient and oxygen exchange while blocking immune components.

Related Experiment Videos

  • Developing and characterizing implantable devices for cell-based therapy.
  • Evaluating immunoisolation strategies in preclinical models, including Alzheimer's and Huntington's disease.

    • Main Results:

    • Immunoisolation successfully protects encapsulated cells from host immune rejection.
    • The technology enables the use of non-human cells, eliminating the need for host immunosuppression.
    • Demonstrated potential in preclinical models for delivering therapeutic molecules across the BBB.

    Conclusions:

    • Cell immunoisolation is a promising approach for treating CNS diseases by overcoming the BBB.
    • Advances in device design and membrane technology are crucial for clinical translation.
    • This strategy offers a viable alternative to systemic drug delivery and chronic immunosuppression.