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Related Experiment Videos

Clinical experience with infants with Robin sequence: a prospective study.

I L Marques1, T V de Sousa, A F Carneiro

  • 1Hospital de Reabilitação de Anomalias Craniofaciais da Universidade de São Paulo, Bauru, SP, Brazil. ilza_marques@uol.com.br

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|April 11, 2001
PubMed
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Robin sequence (RS) patients, particularly those with probable isolated RS and type 1 obstruction, often improve without surgery. Nasopharyngeal intubation (NPI) is recommended for significant respiratory and feeding issues in RS types 1 and 2.

Area of Science:

  • Craniofacial Medicine
  • Pediatric Surgery
  • Neonatology

Background:

  • Robin sequence (RS) is a congenital condition characterized by micrognathia, glossoptosis, and airway obstruction.
  • Early identification and management are crucial for improving outcomes in infants with RS.

Purpose of the Study:

  • To investigate the clinical progression of infants diagnosed with Robin sequence during their first six months of life.
  • To evaluate the effectiveness of various treatment modalities for airway obstruction in RS patients.

Main Methods:

  • A prospective longitudinal study was conducted involving 62 infants with RS.
  • Patients were categorized based on RS presentation: probable isolated RS (PIRS), syndromic RS, and RS with neurological involvement.
  • Respiratory obstruction severity was assessed via nasopharyngoscopy, guiding interventions such as nasopharyngeal intubation (NPI), glossopexy, and tracheostomy.

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Main Results:

  • Prone position treatment (PPT) or NPI served as definitive management for 75.8% of PIRS cases and 52% of syndromic RS cases.
  • A significant proportion of infants with type 1 obstruction (51.1%) improved with PPT alone, while 25.5% required NPI.
  • Infants treated exclusively with NPI demonstrated positive weight, length, and neuromotor development.

Conclusions:

  • The majority of PIRS patients and those with type 1 obstruction experience favorable outcomes without surgical intervention.
  • Nasopharyngeal intubation (NPI) is indicated as a primary treatment for significant respiratory and feeding challenges in Robin sequence patients with type 1 and type 2 obstruction.