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Biofilms and device-associated infections.

R M Donlan1

  • 1Centers for Disease Control and Prevention Atlanta, Georgia 30333, USA. rld8@cdc.gov

Emerging Infectious Diseases
|April 11, 2001
PubMed
Summary

Microorganisms form biofilms on medical devices, increasing antimicrobial resistance. Further research on sampling, drug resistance, and infection links is crucial for controlling these resilient biofilms.

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Area of Science:

  • Microbiology
  • Biomedical Engineering
  • Infectious Diseases

Background:

  • Microorganisms readily colonize surfaces, forming biofilms composed of extracellular polymers.
  • Biofilm-embedded microbes exhibit significant resistance to antimicrobial agents and strong surface adhesion.
  • Biofilms on indwelling medical devices pose a substantial clinical challenge.

Purpose of the Study:

  • To highlight the need for improved understanding and control of biofilms on medical devices.
  • To identify key research areas for addressing biofilm-related challenges.
  • To emphasize the clinical significance of biofilm formation in healthcare settings.

Main Methods:

  • This study is a review and synthesis of current knowledge on microbial biofilms.
  • It focuses on the challenges posed by biofilms in the context of indwelling medical devices.
  • The approach involves identifying critical research gaps and future directions.

Main Results:

  • Microbial biofilms demonstrate high resistance to antimicrobial treatments.
  • Biofilms exhibit tenacious binding to surfaces, complicating removal.
  • A clear link between biofilm contamination and patient infection is often observed.

Conclusions:

  • Developing reliable sampling and measurement techniques for biofilms is essential.
  • Investigating the role of biofilms in antimicrobial drug resistance is a critical research area.
  • Establishing the definitive link between biofilm contamination and patient infection is necessary for effective intervention.

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