Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusion MRI in ischemic stroke compared to pathologically verified infarction.

P J Kelly1, E T Hedley-Whyte, J Primavera

  • 1Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA. pjkelly@partners.org

Neurology
|April 11, 2001
PubMed
Summary

Diffusion MRI accurately detects ischemic stroke, correlating well with autopsy findings. This imaging technique shows high sensitivity and specificity for identifying infarction, aiding clinical diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

'Pontinization' of the medulla: two clinical case studies.

Neuropathology and applied neurobiology·2011
Same author

RADIOAUTOGRAPHY OF CHOLESTEROL IN LUNG : An Assessment of Different Tissue Processing Techniques.

The Journal of cell biology·2009
Same author

Myelin: dynamic or stable?

The Journal of general physiology·2009
Same author

Multiple Symmetric Lipomatosis (Madelung's Disease) Caused by the MERRF (A8344G) Mutation: A Report of Two Cases and Review of the Literature.

Journal of clinical neuromuscular disease·2008
Same author

Adult onset leukodystrophy with neuroaxonal spheroids: clinical, neuroimaging and neuropathologic observations.

Brain pathology (Zurich, Switzerland)·2008
Same author

Facial onset sensory and motor neuronopathy (FOSMN syndrome): a novel syndrome in neurology.

Brain : a journal of neurology·2006

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • Diffusion MRI is a key neuroimaging technique for detecting acute ischemic stroke.
  • Previous studies in animal models show diffusion MRI abnormalities correlate with ischemic stroke pathology.
  • This study investigates the diagnostic accuracy of diffusion MRI in human patients against autopsy confirmation.

Observation:

  • A combined retrospective and prospective analysis included 11 patients with probable ischemic stroke confirmed by autopsy.
  • Diffusion MRI was performed within 28 days of symptom onset and autopsy within 16 weeks.
  • A blinded neuroradiologist identified MRI abnormalities, compared with pathologic records.

Findings:

  • Diffusion MRI correctly identified infarction in 23 out of 25 cases (88.5% sensitivity).

Related Experiment Videos

  • The technique showed high specificity (96.6%) and accuracy (95.1%) in detecting ischemic infarction.
  • Two cases showed MRI abnormalities without infarcts, and two infarcts were missed by MRI.

    • Implications:

    • Diffusion MRI demonstrates high accuracy for detecting ischemic infarction, supporting its clinical utility.
    • These findings validate diffusion MRI as a reliable tool for diagnosing ischemic stroke.
    • The study provides strong evidence for using diffusion MRI in clinical practice for stroke evaluation.