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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression
Published on: March 17, 2020
Pulmonary granular cell tumor coexisting with bronchogenic carcinoma
1Department of Pathology, University of Tennessee, Memphis, TN 38163, USA.
Abstract:
Pulmonary granular cell tumors (GCTs) are uncommon and predominantly benign. The coexistence of GCTs with bronchogenic carcinoma is rare. We report three cases of GCT occurring simultaneously with a primary bronchogenic carcinoma. In one case mucoepidermoid carcinoma was seen colliding with a bronchial submucosal GCT. In another case an endobronchial GCT was seen beneath squamous cell carcinoma in situ and adjacent to invasive squamous carcinoma. In the third case a central bronchial GCT was identified concurrently with a peripheral adenocarcinoma. We suggest that the presence of a GCT should prompt adequate sampling to rule out the coexistence of bronchogenic carcinoma. Clinical awareness and complete evaluation for a malignant primary lung tumor will lead to more appropriate therapy. Ann Diagn Pathol 5:74-79, 2001.
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