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Sesaminol from sesame seed induces apoptosis in human lymphoid leukemia Molt 4B cells

Y Miyahara¹, H Hibasami, H Katsuzaki

¹Kuki Sangyo Co., Ltd., Yokkaichi-city, Mie 510-0059, Japan.

International Journal of Molecular Medicine

|April 11, 2001

Abstract:

The exposure of human lymphoid leukemia Molt 4B cells to sesaminol, a component of sesame oil led to both growth inhibition and the induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with sesaminol. The fragmentation of DNA by sesaminol to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition of Molt 4B cells by sesaminol results from the induction of apoptosis in the cells.

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