Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin D and genomic stability.

M Chatterjee1

  • 1Department of Pharmaceutical Technology, Division of Biochemistry, Jadavpur University, 700032, Calcutta, India. m.chatterjee@mailcity.com

Mutation Research
|April 11, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Read-across-driven binary classification for the developmental and reproductive toxicity of organic compounds tested according to the OECD test guidelines 421/422.

SAR and QSAR in environmental research·2025
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36  TeV with the ATLAS Detector at the LHC.

Physical review letters·2025
Same author

Simultaneous Unbinned Differential Cross-Section Measurement of Twenty-Four Z+jets Kinematic Observables with the ATLAS Detector.

Physical review letters·2025
Same author

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Light Long-Lived Particles in pp Collisions at sqrt[s]=13  TeV Using Displaced Vertices in the ATLAS Inner Detector.

Physical review letters·2024
Same journal

Monoallelic germline RAD51C, RAD51D, and BRIP1 variants in hereditary cancer testing: Variant spectrum and clinical counselling implications.

Mutation research·2026
Same journal

Prediction of hepatocellular carcinoma associated biomarkers in TP53 gene; A comprehensive in silico analysis.

Mutation research·2026
Same journal

IDH1 mutation promotes angiogenesis via upregulation of hypoxia inducible factor 1 alpha in glial tumors.

Mutation research·2026
Same journal

Targeting overexpressed oncogenes in esophageal cancer through miRNA-mediated gene silencing: Insights from binding affinity and thermodynamic profiling.

Mutation research·2026
Same journal

The active compound quercetin from Polygonum cuspidatum targets COL3A1 to enhance CD8⁺ T cell cytotoxicity in gastric cancer.

Mutation research·2026
Same journal

E2F1 promotes LIHC malignant phenotype via NEK2-mediated Wnt/β-catenin and Notch activation and EMT.

Mutation research·2026
See all related articles

Vitamin D (1alpha,25-dihydroxyvitamin D(3)) influences numerous tissues beyond calcium regulation, impacting gene expression through genomic and potentially non-genomic pathways. Its roles extend to cellular protection, proliferation, and implications in cancer processes.

Area of Science:

  • Endocrinology and Molecular Biology
  • Genomics and Cellular Signaling

Background:

  • 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] exhibits non-calcium-homeostasis related functions.
  • Receptors and activities of 1,25(OH)(2)D(3) are documented in diverse tissues including brain, pancreas, skin, and immune cells.
  • The 1,25(OH)(2)D(3) receptor complex binds to Vitamin D responsive elements, modulating gene transcription.

Purpose of the Study:

  • To elucidate the diverse biological actions of 1,25(OH)(2)D(3) beyond calcium homeostasis.
  • To explore the genomic and potential non-genomic mechanisms of Vitamin D action.
  • To highlight the physiological and clinical implications of Vitamin D in various cellular processes and diseases.

Main Methods:

  • Analysis of genomic effects involving Vitamin D responsive elements and gene transcription modulation.

Related Experiment Videos

  • Investigation of Vitamin D's role in regulating specific gene expressions (e.g., carbonic anhydrase, Id genes, oncogenes, insulin receptor, BSP, OPN, aromatase, hpl, cyclin C).
  • Assessment of Vitamin D's effects on cellular processes like oxidative stress, apoptosis, DNA synthesis, and proliferation.

    • Main Results:

    • Genomic actions of Vitamin D influence bone resorption, differentiation, and biosynthesis of various proteins.
    • Vitamin D protects against genotoxic effects, supports placental function, and regulates cell-cycle.
    • Vitamin D exhibits antioxidant properties, induces apoptosis in cancer cells, stabilizes chromosomes, and promotes DNA synthesis.

    Conclusions:

    • Vitamin D plays a significant role in cellular functions, including protection, proliferation, and differentiation, through both genomic and non-genomic pathways.
    • Vitamin D's influence on gene expression has implications for bone metabolism, reproductive health, and cellular integrity.
    • The multifaceted actions of Vitamin D, particularly its anti-cancer properties and role in DNA repair, suggest significant physiological and clinical relevance.