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Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice
M Ramezani1, H Hosseinzadeh, N Daneshmand
1Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, I.R., Mashhad, Iran. mapharm@sinasoft.net
Fitoterapia
|April 11, 2001
Abstract:
The antinociceptive effect of different Elaeagnus angustifolia fruit seed extractives was studied in mice using hot-plate and writhing tests. Following intraperitoneal injection, the decoction (EaDE), the ethanol extract (EaEE), the aqueous and n-butanol fractions (EaAF, and EaBF, respectively) of a polyphenolic fraction, and two flavonoid-enriched fractions of EaBF (EaBCF1 and EaBCF2) showed significant antinociceptive activity in both tests, markedly and dose-dependently increasing the pain threshold.