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Mast cell stabilising activity of Bacopa monnieri
D S Samiulla1, D Prashanth, A Amit
1Bioassay Unit, Research & Development Centre, Natural Remedies Pvt. Ltd., Plot No. 5B, Veerasandra Indl. Area, Hosur Road, 561 229, Bangalore, India.
Fitoterapia
|April 11, 2001
Summary
Bacopa monnieri extracts were evaluated for mast cell stabilization. The methanolic extract showed significant activity, similar to the standard drug disodium cromoglycate.
Area of Science:
- Pharmacology
- Phytochemistry
- Immunology
Background:
- Mast cells play a crucial role in allergic and inflammatory responses.
- Bacopa monnieri is a medicinal herb with a history of traditional use.
- Identifying natural compounds with mast cell stabilizing properties is of therapeutic interest.
Purpose of the Study:
- To investigate the in vitro mast cell stabilizing effects of different Bacopa monnieri extracts.
- To compare the efficacy of Bacopa monnieri extracts with a known mast cell stabilizer.
Main Methods:
- Successive extraction of Bacopa monnieri using petroleum ether, chloroform, methanol, and water.
- In vitro testing of these extracts for mast cell stabilizing activity.
- Comparison of activity with disodium cromoglycate.
Main Results:
- The methanolic extract of Bacopa monnieri demonstrated potent mast cell stabilizing activity.
- The observed activity was comparable to that of disodium cromoglycate.
- Other extracts showed varying degrees of activity.
Conclusions:
- Bacopa monnieri possesses significant mast cell stabilizing properties, particularly its methanolic fraction.
- This finding supports the traditional use of Bacopa monnieri and suggests its potential as a source for anti-allergic or anti-inflammatory agents.