Related Experiment Video
Updated: Jul 24, 2026
13:19
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
The Prostate Cancer Prevention Trial: Current status and lessons learned
I M Thompson1, M Kouril, E A Klein
1Division of Urology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, USA. thompsoni@uthscsa.edu
Urology
|April 11, 2001
Summary
US men readily participate in large prostate cancer prevention trials. Key factors for success include robust data management, staff training, and adaptable study designs for future chemoprevention research.
Area of Science:
- Oncology
- Clinical Trials
- Preventive Medicine
Background:
- The Prostate Cancer Prevention Trial was the first large-scale, phase 3 chemoprevention study for prostate cancer in the United States.
- This trial generated significant data crucial for designing future cancer prevention studies in men.
Purpose of the Study:
- To review the implementation experience of the Prostate Cancer Prevention Trial.
- To identify key lessons learned for conducting future large-scale, randomized cancer chemoprevention trials.
Main Methods:
- Review of implementation experiences from the Prostate Cancer Prevention Trial.
- Analysis of factors contributing to trial success and challenges encountered.
Main Results:
- US men are willing to enroll in prevention trials, viewing them as "men's health trials."
- Trial success depends on participant characteristics (educated, healthy), effective data management, institutional coordination, and staff training.
- Adaptability in study design is necessary due to evolving clinical practices during long-term trials.
Conclusions:
- Large-scale, randomized chemoprevention trials are feasible in the US with proper design, data management, and flexible staffing.
- The insights gained will facilitate future advancements in prostate cancer chemoprevention strategies.
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