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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

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Related Experiment Video

Updated: Jul 19, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

A link between chronic asthma and chronic infection.

R J Martin1, M Kraft, H W Chu

  • 1Department of Medicine, National Jewish Medical and Research Center and The Pulmonary and Critical Care Division, University of Colorado Health Sciences Center, 1400 Jackson St., Denver, CO 80206, USA.

The Journal of Allergy and Clinical Immunology
|April 11, 2001
PubMed
Summary

Chronic asthma may be linked to infections from Mycoplasma and Chlamydia species. Asthmatic patients showed higher mast cell counts, suggesting a role in disease pathophysiology and potential new treatments.

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Related Experiment Videos

Last Updated: Jul 19, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

Area of Science:

  • Respiratory Medicine
  • Infectious Diseases
  • Immunology

Background:

  • Asthma significantly impacts quality of life and incurs economic costs.
  • The precise causes and pathophysiology of asthma remain incompletely understood.
  • Chronic infections are increasingly suspected as contributing factors to asthma.

Purpose of the Study:

  • To investigate the association between Mycoplasma and Chlamydia species and chronic asthma.
  • To compare the prevalence of these microbial species in asthmatic patients versus healthy controls.

Main Methods:

  • A comparative study involving 55 chronic stable asthma patients and 11 healthy controls.
  • Utilized PCR, culture, and serology to detect Mycoplasma, Chlamydia, and viruses in respiratory samples and blood.
  • Assessed bronchoalveolar lavage cell counts, tissue morphometry, and chronic sinusitis severity.

Main Results:

  • PCR detected Mycoplasma or Chlamydia in 31 of 55 asthmatic patients, primarily in lung biopsies and lavage fluid.
  • Only one control subject tested positive for Mycoplasma.
  • Asthmatic patients with positive PCR results exhibited significantly higher tissue mast cell counts.

Conclusions:

  • A substantial proportion of chronic stable asthma patients harbor Mycoplasma or Chlamydia species in their airways.
  • Increased mast cell presence is a key distinguishing feature in these patients.
  • These findings may offer insights into asthma pathophysiology and inform novel therapeutic strategies.