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Clofazimine enteropathy in a pediatric bone marrow transplant recipient
M Parizhskaya1, N N Youssef, C Di Lorenzo
1Department of Pathology, Division of Gastroenterology, Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15513, USA.
The Journal of Pediatrics
|April 11, 2001
Abstract:
Clofazimine, previously used in the treatment of leprosy, is now used for treatment of Mycobacterium avium complex infection in patients with acquired immune deficiency syndrome, dermatologic disorders, and graft-versus-host disease. An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease. Clofazimine enteropathy caused by crystal deposition can be life-threatening.