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Related Experiment Videos

Ethnic differences in fibrinogen levels: the role of environmental factors and the beta-fibrinogen gene.

D G Cook1, F P Cappuccio, R W Atkinson

  • 1Department of Public Health Sciences, St. George's Hospital Medical School, London. d.cook@sghms.ac.uk

American Journal of Epidemiology
|April 11, 2001
PubMed
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Black individuals had lower plasma fibrinogen levels than White individuals, a difference not explained by environmental factors or specific gene variants. These lower fibrinogen levels may contribute to reduced ischemic heart disease risk in Black populations.

Area of Science:

  • Cardiovascular Science
  • Genetics
  • Epidemiology

Background:

  • Fibrinogen is a known cardiovascular risk factor.
  • Ethnic variations in cardiovascular risk are observed, but fibrinogen levels across diverse ethnic groups are not well understood.
  • Understanding these variations is crucial for targeted cardiovascular disease prevention strategies.

Purpose of the Study:

  • To investigate plasma fibrinogen levels in Black, South Asian, and White adults in South London.
  • To examine the association of fibrinogen levels with specific genetic variants in the beta-fibrinogen gene promoter.
  • To explore potential ethnic differences in cardiovascular risk factors.

Main Methods:

  • Plasma fibrinogen levels were measured in 479 Black, 459 South Asian, and 453 White individuals (aged 40-59).

Related Experiment Videos

  • Genotyping was performed for two beta-fibrinogen gene promoter variants: G-455A and C-148T.
  • Statistical analyses were conducted to compare fibrinogen levels across ethnic groups and assess genetic associations, controlling for environmental factors like smoking.

    • Main Results:

    • Black individuals exhibited significantly lower plasma fibrinogen levels compared to White individuals (men: -0.22 g/L, women: -0.11 g/L).
    • South Asian individuals did not show consistent differences in fibrinogen levels compared to White individuals.
    • The T-148 allele was associated with higher fibrinogen levels in Black individuals, contrary to findings in White and South Asian groups where the A-455 and T-148 alleles were less common and associated with lower fibrinogen.

    Conclusions:

    • Lower plasma fibrinogen levels in Black individuals compared to White individuals may partially explain their reduced risk of ischemic heart disease in the UK.
    • Ethnic-specific genetic influences on fibrinogen levels, particularly the T-148 allele, warrant further investigation.
    • These findings highlight the importance of considering ethnic background in the assessment of cardiovascular risk factors.