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Related Experiment Videos

Brain-behavior relationships in obsessive-compulsive disorder.

S Saxena1, R G Bota, A L Brody

  • 1UCLA Obsessive-Compulsive Disorder Research Program, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA. ssaxena@mednet.ucla.edu

Seminars in Clinical Neuropsychiatry
|April 11, 2001
PubMed
Summary
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Neuroimaging reveals that obsessive-compulsive disorder (OCD) symptoms stem from overactive orbitofrontal-subcortical circuits. Serotonergic drugs may help by rebalancing these brain pathways.

Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Obsessive-compulsive disorder (OCD) is increasingly understood through brain-behavior relationships.
  • Neuroimaging advances offer new insights into the neural underpinnings of OCD.

Purpose of the Study:

  • To review and analyze structural and functional neuroimaging studies in OCD.
  • To synthesize neuroimaging evidence and basic science literature to model brain mediation of OCD symptoms and treatment response.

Main Methods:

  • Review of published structural and functional neuroimaging studies in OCD.
  • Integration of basic science literature on cortico-basal ganglia-thalamo-cortical circuits.
  • Development of a theoretical model for OCD brain mediation.

Main Results:

Related Experiment Videos

  • OCD symptoms are associated with hyperactivity in orbitofrontal-subcortical circuits.
  • This hyperactivity may result from an imbalance in striato-pallidal pathways.
  • Serotonergic drugs appear to modulate this imbalance, reducing circuit activity.

Conclusions:

  • Neuroimaging data support a model of OCD pathophysiology involving specific brain circuits.
  • Understanding these circuits offers targets for therapeutic interventions.
  • Modulation of cortico-basal ganglia-thalamo-cortical pathways is key to treating OCD.