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Proton magnetic resonance spectroscopy (H-MRS) studies of schizophrenia
L Rowland1, J R Bustillo, J Lauriello
1Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131, USA.
Abstract:
Proton magnetic resonance spectroscopy ((1)H-MRS) is a noninvasive technique that can quantify biochemical compounds in the brain. (1)H-MRS has been used to investigate neural structures implicated in the pathology of schizophrenia. The majority of research has revealed reduced N-acetylaspartate (NAA), an index of neuronal integrity, in frontal and temporal regions of medicated and chronically ill patients with schizophrenia. This review summarizes basic principles of (1)H-MRS, studies of frontal, temporal, subcortical, and cerebellar regions in schizophrenia. Technical and study design limitations are also discussed.