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[Complications with plasma exchange].

K Kimoto1, M Odaka, N Yuki

  • 1Department of Neurology, Dokkyo University School of Medicine.

Rinsho Shinkeigaku = Clinical Neurology
|April 12, 2001
PubMed
Summary
This summary is machine-generated.

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Plasma exchange (PE) is a common treatment for Guillain-Barré syndrome. This study found that PE complications, such as hypotension and fever, occurred in 28% of sessions, increasing with patient age.

Area of Science:

  • Neurology
  • Nephrology
  • Critical Care Medicine

Context:

  • Plasma exchange (PE) is a recognized treatment for Guillain-Barré syndrome (GBS).
  • In Japan, alternative procedures like double-filtration plasmapheresis and immunoadsorption are frequently used.
  • The safety profile and complication frequency of PE in GBS require further investigation.

Purpose:

  • To determine the frequency of complications associated with plasma exchange in Guillain-Barré syndrome patients.
  • To identify the types and incidence of adverse events during PE therapy.
  • To analyze factors influencing complication rates, such as patient age.

Summary:

  • Complications occurred in 55 out of 197 plasma exchange sessions (28%).
  • The most common complication was transient symptomatic hypotension (16%), followed by fever (10%), nausea/vomiting (7%), chills (5%), headache (5%), tachycardia (2%), and thromboembolism (2%).

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  • No significant bleeding events were reported. Complication frequency increased with patient age.

    • Impact:

    • This study provides crucial data on the safety of plasma exchange for Guillain-Barré syndrome.
    • Findings highlight the need for vigilant monitoring during PE, especially in older patients.
    • Results may inform treatment guidelines and patient management strategies for GBS.