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Localized neurological necrotizing vasculitides. Three cases with isolated mononeuritis multiplex
S Abgrall1, L Mouthon, P Cohen
1Service de Médecine Interne, H pital Avicenne and Université Paris, Nord, Bobigny, France.
The Journal of Rheumatology
|April 12, 2001
Summary
Localized vasculitic neuropathies, affecting nerves and muscles without systemic disease, can be severe and relapsing. This study highlights isolated cases distinct from the typically benign prognosis of such conditions.
Area of Science:
- Neurology
- Immunology
- Pathology
Background:
- Localized vasculitic neuropathies are increasingly recognized in clinical practice.
- Necrotizing vasculitis typically involves systemic organs, but can present with localized manifestations.
Observation:
- Three cases of peripheral neuropathy characterized by necrotizing vasculitis limited to nerves and muscles were observed.
- These patients exhibited no evidence of systemic involvement or non-specific clinical/biological signs of systemic disease.
Findings:
- The described neuropathies were severe and relapsing, challenging the generally accepted benign prognosis of localized vasculitic neuropathies.
- The vasculitis was strictly confined to the peripheral neuromuscular system in these isolated cases.
Implications:
- These findings suggest that isolated vasculitic neuropathies can present with a severe, relapsing course.
- Understanding this distinct presentation is crucial for accurate diagnosis and management of peripheral neuropathies.