Jove
Visualize
Contact Us

Related Experiment Videos

Polyarteritis nodosa.

S M Bonsib1

  • 1Department of Pathology, Medical College of Georgia, Augusta 30912, USA.

Seminars in Diagnostic Pathology
|April 12, 2001
PubMed
Summary

Polyarteritis nodosa is a vasculitis affecting medium and small arteries, causing necrotizing lesions. Early diagnosis and cytotoxic treatment significantly improve patient prognosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyarteritis nodosa of the vagina mimicking vaginal carcinoma.

Journal of lower genital tract disease·2015
Same author

Polyoma viral infection in renal transplantation: the role of immunosuppressive therapy.

Clinical transplantation·2001
Same author

The role of the tubulointerstitium in radiation-induced renal fibrosis.

Radiation research·2001
Same author

Acute rejection-associated tubular basement membrane defects and chronic allograft nephropathy.

Kidney international·2000
Same author

Acute rejection presenting as nephrotic syndrome.

Transplantation·2000
Same author

Renal sinus involvement in renal cell carcinomas.

The American journal of surgical pathology·2000
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Rheumatology
  • Pathology

Background:

  • Polyarteritis nodosa (PAN) is an early-described systemic vasculitis.
  • Characterized by necrotizing lesions in medium and small arteries, often with concurrent reparative changes.

Observation:

  • Necrotizing arterial lesions can lead to aneurysms and significant end-organ damage via ischemia, infarcts, and hemorrhage.
  • Pulmonary involvement is rare, but any organ can be affected.
  • Diagnosis is challenging due to overlapping features with other vasculitides and similar arterial lesions.

Findings:

  • Exclusion criteria for PAN include necrotizing glomerular lesions.
  • Aneurysm formation is a potential consequence of arterial wall weakening.

Implications:

  • Accurate diagnosis requires close collaboration between pathologists and clinicians, integrating clinical and laboratory data.
  • Aggressive treatment with cytotoxic agents has markedly improved the prognosis for polyarteritis nodosa.

Related Experiment Videos