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Angiocentric lymphomas (lymphomatous vasculitis).

Y Natkunam1, R A Warnke

  • 1Department of Pathology, Stanford University Medical Center, CA 94305, USA. ynatkunam@yahoo.com

Seminars in Diagnostic Pathology
|April 12, 2001
PubMed
Summary

Angiocentric lymphomas, a diverse group of blood cancers, are characterized by their unique growth pattern around blood vessels. This article reviews their classification, diagnosis, and clinical features.

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Angiocentric lymphomas are a group of hematolymphoid malignancies defined by their angiocentric or perivascular growth pattern.
  • This category encompasses T-cell, B-cell, and natural killer (NK)-cell derived lymphomas with diverse clinicopathologic features and prognoses.

Purpose of the Study:

  • To outline the salient clinicopathologic features of natural killer (NK) and NK-like T-cell lymphomas.
  • To address the diagnostic challenges associated with these lymphomas.
  • To present an integrated approach for their diagnosis.

Main Methods:

  • Review of clinicopathologic features.
  • Immunophenotypic and molecular characterization.
  • Analysis of diagnostic difficulties and integrated diagnostic strategies.

Main Results:

  • Angiocentric lymphomas are heterogeneous, including T-, B-, and NK-cell derived types.
  • Initial classification focused on NK and NK-like T-cell lymphomas with angiocentric growth.
  • Reclassification based on improved characterization reveals shared features with other lymphomas and leukemias.

Conclusions:

  • Angiocentric lymphomas represent a complex spectrum of malignancies.
  • Accurate diagnosis requires an integrated approach considering morphology, immunophenotype, and molecular data.
  • Distinguishing these from other lymphoid neoplasms is crucial for appropriate patient management.

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