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Systemic lupus erythematosus presenting with generalized lymphadenopathy: a case report
B Biner1, B Acunaş, S Karasalihoğlu
1Department of Pediatrics, Trakya University Faculty of Medicine, Edirne, Turkey.
The Turkish Journal of Pediatrics
|April 12, 2001
Summary
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. This case study details a young female patient with SLE presenting with lymphadenopathy, rash, and pericarditis, highlighting challenges in diagnosis and treatment.
Area of Science:
- Immunology
- Rheumatology
- Pediatrics
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune complex deposition.
- It can affect multiple organ systems, presenting with diverse clinical manifestations.
- Early diagnosis and management are crucial for patient outcomes.
Observation:
- A 13-year-old female presented with generalized lymphadenopathy.
- She subsequently developed a characteristic butterfly rash and pericarditis.
- Diagnosis was confirmed by clinical features and serological markers (ANA, anti-dsDNA).
Findings:
- The patient exhibited active disease with significant renal involvement.
- Despite initial steroid therapy, the disease remained active.
- This case underscores the varied presentations of pediatric SLE.
Implications:
- Lupus lymphadenitis can be an initial presenting sign of SLE in adolescents.
- Aggressive disease and treatment resistance necessitate comprehensive management strategies.
- Reviewing lupus lymphadenitis literature aids in understanding rare presentations.