Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rifabutin-associated hypopyon uveitis in human immunodeficiency virus-negative immunocompetent individuals.

N Bhagat1, R W Read, N A Rao

  • 1Doheny Eye Institute and the Keck School of Medicine of the University of Southern California, 1450 San Pablo Street, Los Angeles, CA 90033.

Ophthalmology
|April 12, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing a platform to investigate the heterogeneity of outcomes for patients with ovarian cancer.

BMJ open quality·2025
Same author

Detection of Yersinia enterocolitica in food: an overview.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014
Same author

Expression of heat shock protein 27 and alpha-crystallins in human retinoblastoma after chemoreduction.

The British journal of ophthalmology·2008
Same author

Retinoblastoma presenting as Coats' disease.

Eye (London, England)·2007
Same author

Early onset vitreous amyloidosis in familial amyloidotic polyneuropathy with a transthyretin Glu54Gly mutation is associated with elevated vitreous VEGF.

The British journal of ophthalmology·2007
Same author

Preference for rizatriptan 10-mg wafer vs. eletriptan 40-mg tablet for acute treatment of migraine.

Cephalalgia : an international journal of headache·2006

Rifabutin can cause hypopyon uveitis in HIV-negative individuals, including those who are immunocompetent. Early recognition and treatment, including rifabutin discontinuation, are key for resolving this serious ocular condition.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Pharmacology

Background:

  • Rifabutin-associated uveitis is a known complication primarily reported in individuals with human immunodeficiency virus (HIV).
  • Limited data exists on its occurrence in HIV-negative populations, especially those who are immunocompetent.

Observation:

  • This study describes three HIV-negative cases of hypopyon uveitis occurring during treatment with rifabutin and clarithromycin for Mycobacterium avium complex infections.
  • One patient was immunosuppressed due to a lung transplant, while two were immunocompetent.

Findings:

  • All patients experienced resolution of hypopyon with topical steroid therapy and, in two cases, discontinuation of rifabutin.
  • Complete resolution of vitreitis was achieved by stopping rifabutin in two patients.

Related Experiment Videos

  • One patient developed chronic low-grade uveitis and vitreitis despite dose reduction of rifabutin.

    • Implications:

    • Rifabutin-induced uveitis can occur in HIV-negative and immunocompetent individuals.
    • This condition can mimic infectious endophthalmitis, necessitating careful diagnosis to avoid unnecessary invasive procedures.
    • Clinicians should maintain a high index of suspicion for drug-induced uveitis in patients on rifabutin, regardless of HIV status.