Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histocompatibility antigens (HL-A) in leprosy.

A Dasgupta, N K Mehra, S K Ghei

    Tissue Antigens
    |April 1, 1975
    PubMed
    Summary

    Human Leukocyte Antigen (HLA) frequencies differ in leprosy patients. A study found decreased HLA-9 in non-lepromatous leprosy, suggesting a potential link between specific HLA antigens and leprosy types.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at sqrt[s_{NN}]=5.02  TeV.

    Physical review letters·2022
    Same author

    Search for a heavy vector resonance decaying to a <math></math>  boson and a Higgs boson in proton-proton collisions at <math> </math>.

    The European physical journal. C, Particles and fields·2021
    Same author

    Precision luminosity measurement in proton-proton collisions at <math> </math> in 2015 and 2016 at CMS.

    The European physical journal. C, Particles and fields·2021
    Same author

    Measurement of the Higgs boson production rate in association with top quarks in final states with electrons, muons, and hadronically decaying tau leptons at <math> </math>.

    The European physical journal. C, Particles and fields·2021
    Same author

    Measurements of production cross sections of the Higgs boson in the four-lepton final state in proton-proton collisions at <math> </math>.

    The European physical journal. C, Particles and fields·2021
    Same author

    MUSiC: a model-unspecific search for new physics in proton-proton collisions at <math> </math>.

    The European physical journal. C, Particles and fields·2021

    Area of Science:

    • Immunogenetics
    • Dermatology
    • Medical Microbiology

    Background:

    • Human Leukocyte Antigen (HLA) system plays a crucial role in immune responses.
    • Leprosy, a complex infectious disease, exhibits variable clinical manifestations.
    • Genetic factors, including HLA antigen profiles, are investigated for their association with disease susceptibility and type.

    Purpose of the Study:

    • To investigate the association between specific Human Leukocyte Antigen (HLA) antigens and leprosy.
    • To compare HLA antigen frequencies in leprosy patients (lepromatous and non-lepromatous) with healthy individuals.

    Main Methods:

    • Standard microlymphocytotoxicity test used to determine HLA antigens.
    • Analysis of 11 HLA antigen specificities in 70 leprosy patients and 40 healthy controls.
    • Comparison of antigen frequencies between patient groups and the normal population.

    Main Results:

    • A marginally significant association of HLA-8 was observed in lepromatous leprosy patients.
    • A decreased frequency of HLA-9 was noted in non-lepromatous leprosy patients compared to controls.
    • No significant differences in other tested HLA antigens were found between leprosy patients and healthy individuals.

    Conclusions:

    • Specific Human Leukocyte Antigen (HLA) antigen frequencies may be associated with different types of leprosy.
    • The findings suggest a potential role for HLA-9 in non-lepromatous leprosy.
    • Further research is warranted to elucidate the precise immunogenetic mechanisms underlying leprosy.

    Related Experiment Videos