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Indomethacin therapy in hydramnios
1Department of Obstetrics and Gynaecology, Seth G. S. Medical College and K. E. M. Hospital, Parel, Mumbai - 400 012, India.
Aim:
The use of indomethacin in treatment of hydramnios was evaluated.
Subjects & Methods:
Twelve patients with symptomatic hydramnios were treated with indomethacin (2.2- 3.0 mg/kg body weight/day).
Results:
The treatment was started at a gestational age of 31.17-/+7.94 weeks and continued for 3.74-/+2.3 weeks. Eleven patients responded to the therapy both subjectively and objectively and pregnancies were prolonged by 4.6-/+3.1 weeks (range 0.1-10 weeks). Five women had term deliveries. Six patients had a favourable perinatal outcome. Four patients who had a known congenital anomaly in the foetus, delivered stillborn babies or had an early neonatal death. One patient who did not follow up after commencing therapy delivered a full-term stillbirth. One patient delivered within 1 day of starting therapy. Indomethacin therapy caused no maternal complications.
Conclusion:
Indomethacin was effective in the management of hydramnios and preventing it's complications.