Osler-Weber-Rendu syndrome. Urologist's view.

Area of Science:

• Urology
• Genetics
• Internal Medicine

Background:

• Hereditary hemorrhagic telangiectasia (HHT) is a genetic disorder affecting blood vessels.
• Hematuria is a potential symptom of HHT, necessitating careful evaluation.

Purpose of the Study:

• To highlight the urologic manifestations of HHT.
• To emphasize the importance of considering HHT in patients with unexplained hematuria.

Main Methods:

• Case report of two patients with HHT and hematuria.
• Review of pathophysiologic aspects and treatment of HHT.

Main Results:

• One patient exhibited characteristic telangiectasias in the bladder, prostate, and prostatic urethra.
• The second patient presented with a bladder tumor.

Conclusions:

• Hematuria in HHT patients requires thorough urologic investigation to exclude other causes.
• HHT should be considered in the differential diagnosis of hematuria of unknown origin.